https://www.stallerlab.com/home daily 1.0 2025-08-28 https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1613608833619-GMXOX4QCAX4EIFPI7NF8/DesignedVariants-04.png Home - How do cells turn on genes? StallerLab combines experiments, computation, AI, and theory to study gene regulation. We focus on how transcription factors activate gene expression in yeast and human cells. With high throughput methods and machine learning, we study the relationship between protein sequence and function. We seek to understand the different types of transcriptional activation domains and the evolution of transcription factors. https://www.stallerlab.com/labart daily 0.75 2024-12-10 https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1611270577719-90TBC0L3NFR0L8AL33IL/MVS_HILS_version1.png LabArt RNAi embryos from Staller et al. 2013. Runner up at Harvard Integrated Life Sciences gallery 2012. M.Staller https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/42819ac7-b09a-43f2-b3f5-620fec571c13/IMG_2598.jpeg LabArt Many lab members have musical talents! https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1611270583662-AS0DA3VZ462XIZ21T8UL/MVS_HILS_version2.png LabArt WT, hb RNAi and bcd RNAi embryos from Staller et al. 2013. Submitted to Harvard Integrated Life Sciences gallery 2012. M.Staller https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/a12fa2be-b08c-4e80-8c18-b830a20acf7e/IMG_2419.jpeg LabArt Lab halloween movie night https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1611270773357-V3FPH6N1PEEMEGO5O5NS/SliderImageai+copy.jpg LabArt 'Floppity Boppity' Alex Holehouse 2017 https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/45fe2464-7456-46b9-b80e-5a2dae2950d9/DSC05544.jpeg LabArt https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1611270777376-JGEZMXBUG990KE83095K/MVS_PosterImage+copy.jpg LabArt Gene Expression Atlases of WT and bicoid RNAi embryos visualized with PointCloudXplore. Giant (green), Hunchback (blue), Kruppel (red), Kinirps (yellow) and even-skipped (magenta). From Staller et al. 2015. M.Staller https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/4489581b-2103-4337-a82f-be4af32b3e77/DSC05561.jpeg LabArt Science art https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1611270773824-N6L014WBI9A4TUWMAXYD/Mediator.png LabArt Defunct model for how transcription factors recruit Mediator. M.Staller June 2013 https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/cb32ffba-1364-4795-981d-cfbd1fbe7080/Screenshot+2024-12-09+at+4.55.30%E2%80%AFPM.png LabArt Shrek halloween costume https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1613176887234-O1H9C3VQ7PWJV6G3YBND/Lizard+whole+%28A%2C+12%2C+3%29.jpeg LabArt Lizard Skeleton. M Staller 2010 https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/ab9ec1c8-baf1-46bc-a99d-5eedce8f3a24/IMG_2633.jpeg LabArt Lab cookie decorating and movie night https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1612982018808-5V7O3VTC77BAZ9LU9GEL/AEM_late2020.png LabArt Acidic Exposure Model 2020 M.Staller https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/7f2d398c-5262-42a8-aacb-375cc7766b40/IMG_2634.jpeg LabArt Lab cookie decorating and movie night https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1613176923824-HGJ2UKV6WYLUX64JLR6L/DSC_2748.jpg LabArt Mary Richardson 2018 https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/8fa6ccc9-041a-488c-924e-bb21de47e72d/IMG_1885.jpeg LabArt Brainstorming https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1612982038513-I0SIX34YJ34HUGQDFHI4/Transcription2021.jpg LabArt Transcription? 2021 M.Staller https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/41a435e5-2e3a-4f58-b24b-50907c6aee72/IMG_3268.jpeg LabArt Pickleball! https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1613176923819-S7KGANIZ39U7BI4NI7MI/DSC_2682.jpg LabArt Mary Richardson 2018 https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/fb653b92-5563-45d1-82c1-35593b0f1d35/IMG_2656.jpeg LabArt Hosting a stop on the CCB holiday lab crawl https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/c0288d13-703c-4b65-a1c4-d830f540ff71/TreeCrop.png LabArt Sumanth Mutte, 2020 https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/7de1395a-78bb-4687-adb1-d8bb835354a0/Image+from+iOS+%281%29.jpg LabArt What happens when savio is down... https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1733875657446-OA0CD5RWKPYWVWC5BYPG/IMG_2640.jpg LabArt Holiday cookie decorating by Marissa Zintel https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1733875641265-5QKFP4O40DKBXY1U4GJE/IMG_2638.jpg LabArt Artistic skills by Caitlin Carmody https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1733875627934-VOZSUO76PBTYTGP0DO3H/IMG_2635.jpg LabArt "Boring" - Aditya https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1733875706565-LLQS9KPQD0J1XX2Q5YAV/IMG_2636.jpg LabArt "Snowflake" - Aditya https://www.stallerlab.com/publications daily 0.75 2024-12-05 https://www.stallerlab.com/research daily 0.75 2024-05-17 https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1613091523179-Q76W2H5LATIT7GF5KQ6Y/ResearchStatementFigsRecovered-09.png Research - Sequence features of activation domains Our high throughput method for studying activation domain variants https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1613092305583-6HUEKDPMFYNB765WJFSL/Figure5-02.png Research - Predicting different types of activation domains We used the balance between hydrophobic and acidic residues to predict activation domains https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1613091597421-4TIBJ49FKHHPBPIUF4IE/AnnotatedHb_bcd-01.png Research - Transcription factor evolution Outside of the DNA binding domain, Hunchback is intrinsically disordered and poorly conserved https://www.stallerlab.com/people daily 0.75 2026-01-26 https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/dc1a8bb3-4c1e-4753-93a8-ff1f527b4674/DSC01209.jpg People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/b4273198-23b5-4199-94b2-90df246d585c/DSC09911.jpg People - Assistant Professor in Residence Max Valentín Staller, PhD Department of Molecular and Cell Biology Center for Computational Biology Max’s lab experience began with Sean Connolly and Jorge Benach at Stony Brook University. Max graduated from Princeton University with a major in Molecular Biology and a minor in Quantitative and Computational Biology, completing a senior thesis with David Botstein. Max completed graduate studies in the Systems Biology program at Harvard University, where he worked with Angela DePace. Max pursued his postdoctoral work at Washington University in St. Louis working with Barak Cohen and Rohit Pappu. Outside of lab, Max enjoys hiking, skiing and cooking. Por qué uso la bandera vieja? En mi oficina esta colgada la bandera Venezolana de mi abuelo. Mi abuelo, Valentín Hernández Acosta trabajó para el gobierno de Venezuela durante muchos años. Él fue quien como ministro de Petróleo y Minas nacionalizó la industria petrolera en Venezuela en 1976. Para honrar esa parte de la historia de mi familia, colgué la bandera Venezolana en mi oficina. Yo no apoyo al gobierno de Maduro ni el legado de Chávez, por eso uso la antigua bandera, la de mi abuelo Valentín. https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/0cf50859-e32f-4eb4-a6db-61107d79de3e/Caitlin_Carmody_Headshot.png People Caitlin Carmody Caitlin is a Postdoc investigating the functional effects of variants of uncertain significance in activation domains of autism associated transcription factors. Caitlin loves artificial frosting and celcius. https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/6e1cf90c-82fb-47fb-ade8-dcac42d91b0a/DSC05354.jpg People Aditya Udupa Aditya is a PhD candidate in MCB. In his free time, he enjoys drinking smoothies and playing basketball. https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/b717ebfb-4fed-4728-99c5-54371e579c87/20240718_MZ_Headshot.jpg People Marissa Zintel Marissa is a PhD student in MCB interested in synthetic activation domains in yeast. Marissa loves strawberries and climbing. She is also unequivocally the best pickleball player in the lab. https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/8b59126d-c3af-4930-8a62-0c22855e5db1/DSC05418.jpg People Scarleth Chalen Ulloa Scarleth is a PhD student in MCB studying serine rich activation domains. She is the only lab member able to keep a plant alive. https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/17c0e1bb-e548-4464-bd24-a0cc0353fcf5/DSC05514.jpg People Claire LeBlanc Claire is a PhD student in CCB studying activation domain evolution in yeast. She enjoys running and thinks that Lilo and Stich is the best movie ever. https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/91cdaa86-adca-44c7-aa1d-ac9586c2e445/DSC01145.jpg People Jayden Wang Jayden is a PhD student in MCB studying activation domain motifs and transcription factor multimerization. Jayden has two leopard geckos and thinks that east coast pizza is far superior to Berkeley pizza. https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/88c54f65-7387-46dd-bf83-532f293b314f/DSC05363.jpg People Sanjana Kotha Sanjana is junior specialist in the lab, studying ASD variants of uncertain significance in TFs. Sanjana is the only lab member to have won the Ticketmaster war and attended the Eras tour. https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/18f3d668-862d-4b06-8f92-4d293401e240/DSC05465.jpeg People Darren Kahan Darren is a PhD student in Biophysics at UC Berkeley, working with Susan Marqusee. https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/07e1ee2a-a498-41f4-9286-f92556a09e93/DSC00028.jpg People Vinson Fan Vinson is a Postdoc using single molecule tracking to study the chromatin association of transcription factors. https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/f21aab0d-4846-4822-91b4-eabb737f524b/DSC05384.jpeg People Pooja Agarwal Pooja is a rising third year student majoring in Computer Science and Molecular Biology at UC Berkeley. https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/d58bfe4f-0470-4560-996c-af6b7f85cb19/1698878492906.jpeg People Daniel Aguilera Daniel is a rising third year in the lab majoring in molecular and environmental biology. https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/a5390a75-7a01-4fc1-9c5c-a974efbbc479/DSC01162.jpg People Gean Hu Gean is a rising fourth year student majoring in Computer Science and Bioengineering at UC Berkeley. https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/28551e1a-c621-4cd8-b853-fc9dfe90866e/DSC05526.jpg People October 2024 https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/af59f788-46d1-4e3c-94b7-c7b4e70bcb73/TIF08442.jpg People October 2023 https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/db06e493-b93a-43cb-b8a8-afae03caa8df/20230804.jpg People August 2023 https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/dfc94dd1-c0aa-4728-aa74-4566055fbbdb/20221031.jpg People Halloween 2022 https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/ac3964f6-2a3f-47a1-a85b-1e6d45d51860/202112.jpg People December 2021 https://www.stallerlab.com/contact daily 0.75 2024-05-20 https://images.squarespace-cdn.com/content/v1/6006246ec8cd610112aaef58/1611270418499-W817W8FNLS3341X6EG03/Koshlandv1 Contact - Address postcards to: 16 Barker Hall Berkeley, CA 94720 The Lab is located in: 171 Koshland Hall Email: mstaller [at] berkeley [dot] edu Photo of Koshland Hall Photo credit: R.B. Wolf https://www.stallerlab.com/lab-culture daily 0.75 2023-03-23 https://www.stallerlab.com/new-page daily 0.75 2026-01-15 https://www.stallerlab.com/news-1 daily 0.75 2026-01-15